Search results for "serotonin 5-HT1A receptor"

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Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity an…

2015

New findings show existence of FGFR1-5-HT1A heteroreceptor complexes in 5-HT nerve cells of the dorsal and median raphe nuclei of the rat midbrain and hippocampus. Synergistic receptor-receptor interactions in these receptor complexes indicated their enhancing role in hippocampal plasticity. The existence of FGFR1-5-HT1A heteroreceptor complexes also in midbrain raphe 5-HT nerve cells open up the possibility that antidepressant drugs by increasing extracellular 5-HT levels can cause an activation of the FGF-2/FGFR1 mechanism in these nerve cells as well. Therefore, the agonist modulation of the FGFR1-5-HT1A heteroreceptor complexes and their specific role is now determined in rat medullary …

AgonistSerotoninmedicine.medical_specialtymedicine.drug_classCellular differentiationBiophysicsHeteroreceptor complexBiologyHeteroreceptorBiochemistrySettore BIO/09 - FisiologiaCell LineMidbrainDorsal raphe nucleusMesencephalonInternal medicinemedicineAnimalsSerotonin 5-HT1A receptorReceptor Fibroblast Growth Factor Type 1Protein Interaction MapsPhosphorylationExtracellular Signal-Regulated MAP KinasesMolecular BiologyNeurons8-Hydroxy-2-(di-n-propylamino)tetralinNeuronal PlasticityRapheDepressionAnimalExtracellular Signal-Regulated MAP KinaseCell BiologySerotonin 5-HT1 Receptor AgonistsNeuronFibroblast growth factor receptorRatsEndocrinologymedicine.anatomical_structurenervous systemReceptor Serotonin 5-HT1AAutoreceptorRatFibroblast Growth Factor 2Serotonin 5-HT1 Receptor AgonistNeuronDimerizationNeuroscienceDepression; Dimerization; Fibroblast growth factor receptor; Heteroreceptor complex; Neuronal plasticity; Serotonin 5-HT1A receptor; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cell Line; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 2; Mesencephalon; Neurons; Phosphorylation; Rats; Receptor Fibroblast Growth Factor Type 1; Receptor Serotonin 5-HT1A; Serotonin; Serotonin 5-HT1 Receptor Agonists; Neuronal Plasticity; Protein Interaction Maps
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Increase of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems via allosteric receptor-receptor int…

2015

The ascending midbrain 5-HT neurons known to contain 5-HT1A autoreceptors may be dysregulated in depression due to a reduced trophic support. New findings show existence of FGFR1-5-HT1A heteroreceptor complexes in the rat hippocampus with a partial characterization of their interface and in midbrain raphe 5-HT nerve cells. With in situ Proximity Ligation Assay (PLA) and supported by co-location of the FGFR1 and 5-HT1A immunoreactivities in midbrain raphe 5-HT cells, evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes were obtained in the dorsal and median raphe nuclei of the Sprague–Dawley rat. Their existence in the rat medullary raphe RN33B cell cultures was also establish…

Agonistmedicine.medical_specialtymedicine.drug_classheteroreceptor complexesBiologyHeteroreceptorMidbrain03 medical and health sciences0302 clinical medicineDorsal raphe nucleusInternal medicinemedicineMultidisciplinaryRapheReceptor-receptor interactionCell biologyEndocrinologymedicine.anatomical_structureserotonin 5-HT1A receptornervous system030220 oncology & carcinogenesisPoster Presentationfibroblast growth factor receptorAutoreceptorNeuron030217 neurology & neurosurgerySpringerPlus
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